(a) In some varieties of domestic cats the gene for fur colour is located on the X chromosome. This gene has two alleles. One allele codes for black fur and the other allele codes for ginger fur. The two alleles are codominant so a heterozygous cat will have fur with patches of black and ginger colours. A cat with fur of two colours is known as a tortoiseshell.
- (a)Using appropriate symbols, construct a genetic diagram to show the results of a cross between a female tortoiseshell cat and a male ginger cat. symbols parent phenotypes tortoiseshell female ginger male parent genotypes gametes offspring genotypes offspring phenotypes[5]
- (b)In humans the TYR gene is involved in the production of a dark pigment, melanin, in some cells. Describe how the expression of the TYR gene leads to the production of melanin.[3]
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- [5] (a) 1 symbols B / XB = (allele for) black (fur) G / XG = (allele for) ginger (fur) ; parents phenotypes tortoiseshell female ginger male 2 parents genotypes XBXG XGY ; 3 gametes XB XG XG Y ; 4 offspring genotypes XBXG XBY XGXG XGY ; 5 offspring phenotypes tortoiseshell female black male ginger female ginger male ;
- [3] (b) any three from: 1 TYR codes for tyrosinase ; 2 converts tyrosine into DOPA ; 3 converts DOPA into dopaquinone ; 4 dopaquinone converted to melanin ;
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