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A-LevelBiologyInherited change9700/42 · May/June 2017 · Q79 Marks

(a) Cats with either black fur or white fur are common in Europe, whereas cats with brown fur are less common. A gene, coding for an enzyme involved in pigment production, has two alleles. • The dominant allele, B, results in black fur. • The recessive allele, b, results in brown fur. A second gene can affect fur colour. • The dominant allele, A, prevents pigment production, resulting in a cat with white fur. • The recessive allele, a, has no effect on fur colour. The two genes are on different pairs of autosomes. Use a genetic diagram to show how a cross between two cats, heterozygous at both loci, can produce offspring with three different colours: white, black and brown. State the expected ratio of the different coloured offspring.

  1. (a)Use a genetic diagram to show how a cross between two cats, heterozygous at both loci, can produce offspring with three different colours: white, black and brown. State the expected ratio of the different coloured offspring.[6]
  2. (b)Suggest how the presence of allele A prevents pigment production.[3]

Mark scheme

Marking points from the official mark scheme (May/June 2017). The mark or mark type is shown in brackets.

  1. [6] parental genotypes AaBb x AaBb; gametes AB Ab aB ab x AB Ab aB ab ; offspring (Punnett square with 16 genotypes) max 2 for all offspring correct max 1 if one error max 0 if more than one error offspring phenotype correctly linked to genotype ; ratio 12 white: 3 black: 1 brown;
  2. [max 3] 1. example of, gene interaction / epistasis ; 2. ref. to blocking (one step in) pathway to pigment production; 3. (allele A) product / protein, inhibits enzyme (producing pigment) ; 4. (allele A) product / protein, is a repressor ; A allele codes for a repressor 5. (which) blocks transcription / RNA polymerase cannot bind / switches off allele (coding for pigment) ; 6. (by), binding to / blocking, operator/ promoter ; 7. (allele A) product / protein, prevents transcription factor complex formation / AW ;

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About this question

Topic
Inherited change, A-Level Biology (syllabus 9700). Structured question, 9 marks.
Source
A-Level Biology, May/June 2017 Paper 4 Variant 2, question 7.

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