Amino acids are the monomers that are used to produce proteins in organisms. Amino acids also have other, non-protein, roles in the body. Fig. 7.1 shows the structures of five amino acids with varying numbers and arrangements of carbon atoms. [Figure 7.1]
- (a)In the liver, one of these amino acids can be converted to pyruvate and one of these amino acids can be converted to oxaloacetate. Suggest which of the amino acids shown in Fig. 7.1 would be most directly converted to: • pyruvate • oxaloacetate. amino acid converted to pyruvate amino acid converted to oxaloacetate[2]
- (b)(i)The amino acid glycine can act as a neurotransmitter. A glycinergic synapse is shown in Fig. 7.2. The glycinergic synapse and a cholinergic synapse use different neurotransmitters and different postsynaptic receptors. Describe differences between the glycinergic synapse shown in Fig. 7.2 and a cholinergic synapse.[2]
- (b)(ii)The binding of glycine to receptors, as shown in Fig. 7.2, makes an action potential less likely to occur in the postsynaptic neurone. Suggest why an action potential is less likely to occur after the binding of glycine to receptors.[2]
- (b)(iii)Neurones need to maintain a resting potential before an action potential can occur. Describe how a neurone maintains a resting potential.[4]
This question uses a diagram from the original paper, which isn't shown here. Open the full paper from the past papers archive to see it.
Mark scheme
Marking points from the official mark scheme (May/June 2023). The mark or mark type is shown in brackets.
- (pyruvate) - serine ;
- (oxaloacetate) – asparagine ;
- 1 chloride (ions) / Cl-, not, sodium ions / Na+ (enter post-synaptic neurone) ;
- 2 glycine not choline (re-enters / recycled to, pre-synaptic neurone) OR glycine not, broken down / hydrolysed, but acetylcholine is (in synaptic cleft) ;
- 1 Cl- decreases, membrane / resting, potential (difference) / voltage ;
- 2 harder / need more depolarisation, to reach threshold;
- 3 glycine is inhibitory;
- 1 sodium-potassium pump / active transport ;
- 2 Na+, out / leaves and K+, in / enters ;
- 3 three Na+ for two K+ ;
- 4 some K+ can diffuse out of neurone OR (×20) more K+ diffuses out than Na+ diffuses in OR membrane is (×20) more permeable to K+ (than Na+) ;
- 5 inside of, axon / neurone, is more negative (than outside) OR outside of, axon / neurone, is more positive (than inside) ;
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