In a healthy mammalian heart, contraction of the four chambers is coordinated by the action of the sinoatrial node (SAN) and atrioventricular node (AVN). Fig. 2.1 shows blood pressure changes that occur in the left ventricle, left atrium and aorta during one cardiac cycle. E, F, G and H are the points at which a valve opens or closes as a result of blood pressure changes.
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