Enzyme inhibitors and monoclonal antibodies can be used in the treatment of disease.

Mark scheme

Marking points from the official mark scheme (May/June 2018). The mark or mark type is shown in brackets.

1. [3] three from:
2. same / similar, shape as, HMG CoA / substrate ;
3. complementary (shape) to active site (shape);
4. binds / attaches / fits into / active site (of, enzyme / HMG CoA reductase) ;
5. HMG CoA / substrate, cannot bind (to active site) ; A no / few, enzyme/substrate complexes form I product not made
6. mevalonic acid production, decreases / stops ;
7. AVP; e.g. increase in mevinolin concentration increases inhibition / ora
8. [2] two from:
9. treatment of disease
10. I statements about locating or diagnosis of disease
11. specific / targeted, therapy / treatment ; A specific to diseased, cells / tissue A examples
12. bind to / recognition of, receptors / antigens, on cell surface (of diseased cells) ;
13. kill the cell by stimulating the immune system / AW ; A correct immune responses e.g. stimulates phagocytosis / activates B-cells
14. attach, radioactive substance / drug (to treat / kill diseased cells) / AW ;
15. treat infectious diseases / bind to (antigens on) pathogens / recognition of antigens on pathogens; I bacteria unless stated that they cause disease allow examples such as treatment of ebola or rabies or tetanus (by immunising with antibody) A viruses