Giant axonal neuropathy (GAN) is a rare autosomal recessive disease, which affects neurones.
(a) Mitochondria can move freely within the axons of neurones.
In GAN, the axons of neurones become enlarged and blocked by the accumulation of specific proteins. This prevents the free movement of mitochondria and affects the transmission of action potentials along the axon membrane.

Q: What topic does this question test?

This question tests Control and coordination in A-Level Biology (syllabus code 9700). It is worth 10 marks.

Q: Which exam paper is this question from?

This question appeared in the Cambridge A-Level Biology Feb/Mar 2022 examination, Paper 4 Variant 2 (9700_m22_qp_42.pdf).

Question

Giant axonal neuropathy (GAN) is a rare autosomal recessive disease, which affects neurones.
(a) Mitochondria can move freely within the axons of neurones.
In GAN, the axons of neurones become enlarged and blocked by the accumulation of specific proteins. This prevents the free movement of mitochondria and affects the transmission of action potentials along the axon membrane.

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