Triglycerides and phospholipids are types of lipid. Fig. 2.1 shows the structure of one type of phospholipid known as phosphatidylcholine. F1 and F2 are fatty acid residues. [Figure 2.1]
- (a)Phospholipase is an enzyme that can break down phospholipids. This enzyme is found in the venom of some insects, such as bees. Bee venom can destroy red blood cells, a condition known as haemolysis. Suggest how bee venom destroys red blood cells.[2]
- (b)Compare, stating similarities and differences, the structure of the phosphatidylcholine shown in Fig. 2.1 with the structure of a triglyceride molecule.[4]
- (c)Name and describe the cell structure in which the synthesis of triglycerides and other lipids takes place.[3]
This question uses a diagram from the original paper, which isn't shown here. Open the full paper from the past papers archive to see it.
Mark scheme
Marking points from the official mark scheme (Oct/Nov 2017). The mark or mark type is shown in brackets.
- [2] two from
- cell (surface) membrane / plasma membrane / phospholipid bilayer, damaged / AW ; A phospholipids are in cell surface membrane (and will be broken down by phospholipase)
- cell, bursts / lyses / lysis / ruptures ; haemolysis is neutral
- cell contents / AW / haemoglobin, leaks out / AW ; I water
- [4] allow, fatty acids / fatty acid tails / hydrocarbon chains, for fatty acid residues
- both have / similarities (max 3)
- glycerol (residue) ;
- fatty acids ; I ref. to saturation, R both have, two / three, fatty acids
- ester, bonds / linkages ;
- C and H and O ;
- double bonds ; A both have C=O
- differences (max 3)
- triglyceride / fat / oil / lipid
- no, choline / nitrogen
- A no / small / delta, charges
- or
- phosphatidylcholine / phospholipid
- has, choline / nitrogen ;
- A choline / nitrogen, ion
- A charged / ionic
- three fatty acid residues
- or one extra fatty acid residue ;
- A triglyceride has three ester bonds
- or
- R if comparison includes phosphatidylcholine and the number of fatty acid residues is incorrect
- no, phosphate (group) / phosphorus
- A no, phosphoester / phosphodiester bond
- or
- has phosphate ;
- A has phosphoester / phosphodiester bond
- [3] smooth endoplasmic reticulum ; A smooth ER RSER R if more than one organelle given R endoplastic
- two from
- membranous / membranes ; A ref. to vesicles, formed / bud off R envelope / double membrane
- tubular; A cisternae but R if described as flattened
- fluid filled, channels / sacs ;
- not associated with ribosomes ;
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