A-LevelBiologyThe mitotic cell cycle9700/12 · Feb/Mar 2025 · Q221 Mark
The statements are about two genes and their protein products that can have a role in tumour formation. • The protein coded for by the PTEN gene prevents cells from growing and dividing too rapidly. • The protein coded for by the p53 gene prevents cells progressing through the mitotic cell cycle if the cells have damaged DNA. Which combination of mutations of these two genes in an individual is most likely to result in the formation of a tumour?
APTEN: mutation present, p53: mutation present
BPTEN: no mutation, p53: mutation present
CPTEN: mutation present, p53: no mutation
DPTEN: no mutation, p53: no mutation
✓ Correct answer
A: PTEN: mutation present, p53: mutation present
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