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A-LevelBiologyGas exchangeOct/Nov 2025Paper 1 Q341 Mark

The diagram shows the Bohr shift in actively respiring cells. [Graph showing percentage saturation of haemoglobin with oxygen against partial pressure of oxygen/kPa, with curves L and M] What causes the shift from L to M?

ACarbonic acid dissociates to release protons that bind to oxyhaemoglobin, affecting the conformation of haemoglobin to reduce its affinity for oxygen.
BHydrogencarbonate ions produced by carbonic anhydrase alter the charge of oxyhaemoglobin, reducing its ability to bind oxygen.
CHydrogen ions combine with chloride ions in tissue fluid to produce hydrochloric acid, distorting oxyhaemoglobin and causing it to lose bound oxygen.
Dlow concentration of oxygen in actively respiring cells causes oxyhaemoglobin to release oxygen more quickly down the concentration gradient.

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The correct answer is A. This question tests the candidate's understanding of gas exchange within the Biologysyllabus. The examiner's mark scheme requires...

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About This A-Level Biology Question

This multiple-choice question appeared in the Cambridge A-Level Biology (9700) Oct/Nov 2025 examination, Paper 1 Variant 2. It tests the topic of Gas exchange and is worth 1 mark.

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