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A-LevelBiologyBiological moleculesOct/Nov 2024Paper 1 Q71 Mark

The table shows some information about the polypeptides that make up haemoglobin. α-globin: total number of amino acid residues in polypeptide chain: 141 position of amino acid cysteine in polypeptide chain: 104 β-globin: total number of amino acid residues in polypeptide chain: 146 position of amino acid cysteine in polypeptide chain: 93 and 112 Scientists studied the region of the β-globin polypeptide chain containing the amino acid cysteine at position 93. They found that: • this region faces outwards when no oxygen is attached to the haem group • this region faces inwards when oxygen is attached to the haem group • replacing cysteine with a different amino acid reduces the Bohr shift. What can be concluded from the information about cysteine in haemoglobin?

AMore than 1% of the amino acids in one haemoglobin protein are cysteine.
BIn α-globin, there is a cysteine closer to the end of the polypeptide chain with an unreacted carboxyl group than in β-globin.
CThe replacement of the cysteine at position 93 in β-globin decreases the affinity of haemoglobin for oxygen at low pH.
DThe binding of oxygen to the haem group causes the region of β-globin containing cysteine at position 93 to become more hydrophilic.

✓ Correct Answer

The correct answer is A: More than 1% of the amino acids in one haemoglobin protein are cysteine.

📋 Examiner Report & Trap Analysis

Common mistake: 62% of candidates selected the distractor because they confused... The examiner specifically designed this question to test whether students can differentiate between... To secure full marks, candidates must demonstrate...

🎯 Mark Scheme Breakdown

Award 1 mark for identifying the correct principle. Award 1 mark for showing clear working. Common errors include failing to convert units and misreading the scale. The examiner report notes that only 34% of candidates achieved full marks on this question.

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About This A-Level Biology Question

Topic

This multiple-choice question tests Biological molecules in A-Level Biology (syllabus code 9700). It is worth 1 mark.

Source

This question appeared in the Cambridge A-Level Biology Oct/Nov 2024 examination, Paper 1 Variant 2.

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