A-LevelBiologyInherited changeMay/June 2021Paper 4 Q79 Marks
(a) Haemoglobin is made of two α-globin chains and two β-globin chains. A person may have a mutation in the gene coding for β-globin. This is due to a base substitution and leads to the production of abnormal β-globin and therefore abnormal haemoglobin. A person who is homozygous for the mutant allele will have a condition called sickle cell anaemia.
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